SLAS Discovery Editor’s Top 10 for 2021

The SLAS Discovery Editor’s Top 10 for 2021 (editorial)
Robert M. Campbell

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones.
Ishida, T. and Ciulli, A.
SLAS Disc. 2021, 26, 484-502.

A High-Throughput RNA Displacement Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex toward Developing Therapeutics for COVID-19.
Perveen, S.; Khalili Yazdi, A.; Devkota, K.; et al.
SLAS Disc. 2021, 26, 620-627.

Selecting Approaches for Hit Identification and Increasing Options by Building the Efficient Discovery of Actionable Chemical Matter from DNA-Encoded Libraries.
Foley, T.L.; Burchett, W.; Chen, Q.; et al.
SLAS Disc. 2021, 26, 263-280.

Target Validation Using PROTACs: Applying the Four Pillars Framework.
Nowak, R.P. and Jones, L.H.
SLAS Disc. 2021, 26, 474-483.

Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors.
Lacey, B.M.; Xu, Z.; Chai, X.; et al.
SLAS Disc. 2021, 26, 88-99.

A Tale of Two Tails: Efficient Profiling of Protein Degraders by Specific Functional and Target Engagement Readouts.
Chernobrovkin, A.L.; Cázares-Körner, C.; Friman, T.; et al.
SLAS Disc. 2021, 26, 534-546.

High-Throughput Mass Spectrometry for Hit Identification: Current Landscape and Future Perspectives.
McLaren, D.G.; Shah, V.; Wisniewski, T.; et al.
SLAS Disc. 2021, 26, 168-191.

MALDI-TOF-Based Affinity Selection Mass Spectrometry for Automated Screening of Protein–Ligand Interactions at High Throughput.
Simon, R.P.; Winter, M.; Kleiner, C.; et al.
SLAS Disc. 2021, 26, 44-57.

High-Throughput Quantitative Assay Technologies for Accelerating the Discovery and Optimization of Targeted Protein Degradation Therapeutics.
Simard, J.R.; Lee, L.; Vieux, E.; et al.
SLAS Disc. 2021, 26, 503-517.

A Scalable Approach Reveals Functional Responses of iPSC Cardiomyocyte 3D Spheroids.
Burnham, M.P.; Harvey, R.; Sargeant, R.; et al.
SLAS Disc. 2021, 26, 352-363.

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