SLAS Discovery

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2022
2021

The SLAS Discovery Editor's Top 10 for 2022

Robert M. Campbell

DOI: https://doi.org/10.1016/j.slasd.2023.01.004

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Discovery of SARS-CoV-2 main protease covalent inhibitors from a DNA-encoded library selection

Rui Ge, Zuyuan Shen, Jian Yin, Wenhua Chen, Qi Zhang, Yulong An, Dewei Tang, Alexander L. Satz, Wenji Su, Letian Kuai

DOI: https://doi.org/10.1016/j.slasd.2022.01.001

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Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines

David A. Close, Paul A. Johnston

DOI: https://doi.org/10.1016/j.slasd.2021.10.008

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Lead identification using 3D models of pancreatic cancer

Virneliz Fernandez-Vega, Shurong Hou, Dennis Plenker, Hervé Tiriac, Pierre Baillargeon, Justin Shumate, Louis Scampavia, Jan Seldin, Glauco R. Souza, David A. Tuveson, Timothy P. Spicer

DOI: https://doi.org/10.1016/j.slasd.2022.03.002

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Mass spectrometry-based proteomics of 3D cell culture: A useful tool to validate culture of spheroids and organoids

Thayna Mendonca Avelino, Marta García-Arévalo, Felipe Rafael Torres, Marieli Mariano Goncalves Dias, Romenia Ramos Domingues, Murilo de Carvalho, Matheus de Castro Fonseca, Vanessa Kiraly Thomaz Rodrigues, Adriana Franco Paes Leme, Ana Carolina Migliorini Figueira

DOI: https://doi.org/10.1016/j.slasd.2021.10.013

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Development of high-throughput lacrimal gland organoid platforms for drug discovery in dry eye disease

Teerapat Rodboon, Supansa Yodmuang, Risa Chaisuparat, Joao N. Ferreira

DOI: https://doi.org/10.1016/j.slasd.2021.11.002

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Multifunctional profiling of triple-negative breast cancer patient-derived tumoroids for disease modeling

Evan F Cromwell, Oksana Sirenko, Ekaterina Nikolov, Matthew Hammer, Courtney K Brock, Margarite D Matossian, Madlin S Alzoubi, Bridgette M Collins-Burow, Matthew E Burow

DOI: https://doi.org/10.1016/j.slasd.2022.01.006

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A high throughput screening assay for inhibitors of SARS-CoV-2 pseudotyped particle entry

Miao Xu, Manisha Pradhan, Kirill Gorshkov, Jennifer D. Petersen, Min Shen, Hui Guo, Wei Zhu, Carleen Klumpp-Thomas, Sam Michael, Misha Itkin, Zina Itkin, Marco R. Straus, Joshua Zimmerberg, Wei Zheng, Gary R. Whittaker, Catherine Z. Chen

DOI: https://doi.org/10.1016/j.slasd.2021.12.005

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Identification of potent small molecule inhibitors of SARS-CoV-2 entry

Sonia Mediouni, Huihui Mou, Yuka Otsuka, Joseph Anthony Jablonski, Robert Scott Adcock, Lalit Batra, Dong-Hoon Chung, Christopher Rood, Ian Mitchelle S. de Vera, Ronald Rahaim Jr., Sultan Ullah, Xuerong Yu, Yulia A. Getmanenko, Nicole M. Kennedy, Chao Wang, Tu-Trinh Nguyen, Mitchell Hull, Emily Chen, Thomas D. Bannister, Pierre Baillargeon, Louis Scampavia, Michael Farzan, Susana T. Valente, Timothy P. Spicer

DOI: https://doi.org/10.1016/j.slasd.2021.10.012

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Screening for modulators of autism spectrum disorder using induced human neurons

Sumitha Rajendra Rao, Ana Kostic, Pierre Baillargeon, Virneliz Fernandez-Vega, Mitzy Rios de Anda, Kelty Fletcher, Justin Shumate, Louis Scampavia, Joseph D Buxbaum, Timothy P. Spicer

DOI: https://doi.org/10.1016/j.slasd.2022.01.004

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Adipocyte-based high throughput screening for anti-obesity drug discovery: Current status and future perspectives

Leo Tsui

DOI: https://doi.org/10.1016/j.slasd.2022.08.001

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The SLAS Discovery Editor's Top 10 for 2021

Robert M. Campbell

DOI: https://doi.org/10.1016/j.slasd.2022.01.005

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E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

Tasuku Ishida, Alessio Ciulli

DOI: https://doi.org/10.1177/2472555220965528

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A High-Throughput RNA Displacement Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex toward Developing Therapeutics for COVID-19

Sumera Perveen, Aliakbar Khalili Yazdi, Kanchan Devkota, Fengling Li, Pegah Ghiabi, Taraneh Hajian, Peter Loppnau, Albina Bolotokova, Masoud Vedadi

DOI: https://doi.org/10.1177/2472555220985040

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Selecting Approaches for Hit Identification and Increasing Options by Building the Efficient Discovery of Actionable Chemical Matter from DNA-Encoded Libraries

Timothy L. Foley, Woodrow Burchett, Qiuxia Chen, Mark E. Flanagan, Brendon Kapinos, Xianyang Li, Justin I. Montgomery, Anokha S. Ratnayake, Hongyao Zhu, Marie-Claire Peakman

DOI: https://doi.org/10.1177/2472555220979589

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Target Validation Using PROTACs: Applying the Four Pillars Framework

Radosław P. Nowak, Lyn H. Jones

DOI: https://doi.org/10.1177/2472555220979584

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Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors

Brian M. Lacey, Zangwei Xu, Xiaomei Chai, Jason Laskey, Xavier Fradera, Payal Mittal, Sasmita Mishra, Jennifer Piesvaux, Peter Saradjian, Lynsey Shaffer, Galya Vassileva, Catherine Gerdt, Yun Wang, Heidi Ferguson, Dustin M. Smith, Jeanine Ballard, Steven Wells, Rishabh Jain, Uwe Mueller, George Addona, Ilona Kariv, Joey L. Methot, Mark Bittinger, Sheila Ranganath, Robbie Mcleod, Alexander Pasternak, J. Richard Miller, Haiyan Xu

DOI: https://doi.org/10.1177/2472555220952071

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A Tale of Two Tails: Efficient Profiling of Protein Degraders by Specific Functional and Target Engagement Readouts

Alexey L. Chernobrovkin, Cindy Cázares-Körner, Tomas Friman, Isabel Martin Caballero, Daniele Amadio, Daniel Martinez Molina

DOI: https://doi.org/10.1177/2472555220984372

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High-Throughput Mass Spectrometry for Hit Identification: Current Landscape and Future Perspectives

David G. McLaren, Vinit Shah, Thomas Wisniewski, Lucien Ghislain, Chang Liu, Hui Zhang, S. Adrian Saldanha

DOI: https://doi.org/10.1177/2472555220980696

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MALDI-TOF-Based Affinity Selection Mass Spectrometry for Automated Screening of Protein–Ligand Interactions at High Throughput

Roman P. Simon, Martin Winter, Carola Kleiner, Lucie Wehrle, Michael Karnath, Robert Ries, Markus Zeeb, Gisela Schnapp, Dennis Fiegen, Tim T. Häbe, Frank Runge, Tom Bretschneider, Andreas H. Luippold, Daniel Bischoff, Wolfgang Reindl, Frank H. Büttner

DOI: https://doi.org/10.1177/2472555220959266

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High-Throughput Quantitative Assay Technologies for Accelerating the Discovery and Optimization of Targeted Protein Degradation Therapeutics

Jeffrey R. Simard, Linda Lee, Ellen Vieux, Reina Improgo, Trang Tieu, Andrew J. Phillips, Stewart L. Fisher, Roy M. Pollock, Eunice Park

DOI: https://doi.org/10.1177/2472555220985049

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A Scalable Approach Reveals Functional Responses of iPSC Cardiomyocyte 3D Spheroids

Matthew P. Burnham, Rachel Harvey, Rebecca Sargeant, Niels Fertig, Malcolm Haddrick

DOI: https://doi.org/10.1177/2472555220975332

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SLAS Discovery Editor’s Top 10 for 2022

The SLAS Discovery Editor's Top 10 for 2022

Discovery of SARS-CoV-2 main protease covalent inhibitors from a DNA-encoded library selection

Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines

Lead identification using 3D models of pancreatic cancer

Mass spectrometry-based proteomics of 3D cell culture: A useful tool to validate culture of spheroids and organoids

Development of high-throughput lacrimal gland organoid platforms for drug discovery in dry eye disease

Multifunctional profiling of triple-negative breast cancer patient-derived tumoroids for disease modeling

A high throughput screening assay for inhibitors of SARS-CoV-2 pseudotyped particle entry

Identification of potent small molecule inhibitors of SARS-CoV-2 entry

Screening for modulators of autism spectrum disorder using induced human neurons

Adipocyte-based high throughput screening for anti-obesity drug discovery: Current status and future perspectives

SLAS Discovery Editor’s Top 10 for 2021

The SLAS Discovery Editor's Top 10 for 2021

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

A High-Throughput RNA Displacement Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex toward Developing Therapeutics for COVID-19

Selecting Approaches for Hit Identification and Increasing Options by Building the Efficient Discovery of Actionable Chemical Matter from DNA-Encoded Libraries

Target Validation Using PROTACs: Applying the Four Pillars Framework

Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors

A Tale of Two Tails: Efficient Profiling of Protein Degraders by Specific Functional and Target Engagement Readouts

High-Throughput Mass Spectrometry for Hit Identification: Current Landscape and Future Perspectives

MALDI-TOF-Based Affinity Selection Mass Spectrometry for Automated Screening of Protein–Ligand Interactions at High Throughput

High-Throughput Quantitative Assay Technologies for Accelerating the Discovery and Optimization of Targeted Protein Degradation Therapeutics

A Scalable Approach Reveals Functional Responses of iPSC Cardiomyocyte 3D Spheroids