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Podcast Editor Rob Howes discusses the SLAS Discovery 2020 February Special Issue with Martin Main and Andrew Zhang. To read their editorial, click here.
In this Special Issue of SLAS Discovery, the authors explore multiple aspects of cellular target engagement; from direct measurement of compound-target interaction using BRET technologies, through measurement of compound induced changes in protein stability and localisation, to in vivo drug distribution and target engagement studies. They also highlight technologies that enable a more holistic view of target engagement by mapping multiple compound-protein interactions in a single study. When applied in combination, these methods can build a strong platform of evidence linking compound to target to biological response, thereby impacting project attrition and medicines discovery success.